BDBM50161999 (R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluorophenyl)-6-methylpyrimidine-2,4(1H,3H)-dione::3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL359810

SMILES: Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F

InChI Key: InChIKey=FSEVJYLGSSELNC-QHCPKHFHSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50161999   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50161999 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F |r,wD:14.15,(17.08,-29.9,;15.75,-29.13,;15.75,-27.59,;17.08,-26.82,;18.41,-27.59,;19.74,-26.82,;19.74,-25.28,;18.4,-24.51,;17.07,-25.28,;15.73,-24.52,;14.42,-26.81,;14.42,-25.27,;13.09,-27.59,;11.75,-26.82,;10.42,-27.6,;10.43,-29.14,;9.09,-26.83,;9.09,-25.29,;7.76,-24.53,;6.42,-25.3,;6.43,-26.85,;7.77,-27.61,;13.09,-29.13,;11.76,-29.9,;14.42,-29.89,;14.42,-31.43,;15.75,-32.2,;17.07,-31.43,;15.73,-30.66,;18.41,-32.19,;18.41,-33.74,;17.08,-34.51,;15.74,-33.74,;14.41,-34.51,)| Show InChI InChI=1S/C26H22F3N3O2/c1-16-24(18-10-5-6-11-20(18)27)25(33)32(15-23(30)17-8-3-2-4-9-17)26(34)31(16)14-19-21(28)12-7-13-22(19)29/h2-13,23H,14-15,30H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50161999 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F |r,wD:14.15,(17.08,-29.9,;15.75,-29.13,;15.75,-27.59,;17.08,-26.82,;18.41,-27.59,;19.74,-26.82,;19.74,-25.28,;18.4,-24.51,;17.07,-25.28,;15.73,-24.52,;14.42,-26.81,;14.42,-25.27,;13.09,-27.59,;11.75,-26.82,;10.42,-27.6,;10.43,-29.14,;9.09,-26.83,;9.09,-25.29,;7.76,-24.53,;6.42,-25.3,;6.43,-26.85,;7.77,-27.61,;13.09,-29.13,;11.76,-29.9,;14.42,-29.89,;14.42,-31.43,;15.75,-32.2,;17.07,-31.43,;15.73,-30.66,;18.41,-32.19,;18.41,-33.74,;17.08,-34.51,;15.74,-33.74,;14.41,-34.51,)| Show InChI InChI=1S/C26H22F3N3O2/c1-16-24(18-10-5-6-11-20(18)27)25(33)32(15-23(30)17-8-3-2-4-9-17)26(34)31(16)14-19-21(28)12-7-13-22(19)29/h2-13,23H,14-15,30H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc Curated by ChEMBL					Assay Description Binding affinity at human GnRH receptor				J Med Chem 51: 3331-48 (2008) Article DOI: 10.1021/jm701249f BindingDB Entry DOI: 10.7270/Q2KD1XQ0
					More data for this Ligand-Target Pair