BDBM50162017 3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-1-(5-fluoro-2-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL362065

SMILES: Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1cc(F)ccc1C(F)(F)F

InChI Key: InChIKey=CDBHRNGOYLXFNO-QHCPKHFHSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50162017   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50162017 (3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)...) Show SMILES Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1cc(F)ccc1C(F)(F)F |wD:14.15,(3.83,-.8,;2.5,-.03,;2.5,1.51,;3.83,2.28,;5.16,1.49,;6.49,2.26,;6.49,3.8,;5.16,4.57,;3.83,3.8,;2.5,4.59,;1.17,2.28,;1.17,3.82,;-.16,1.51,;-1.49,2.28,;-2.82,1.49,;-2.82,-.05,;-4.15,2.26,;-5.48,1.49,;-6.81,2.26,;-6.83,3.8,;-5.48,4.57,;-4.15,3.8,;-.16,-.03,;-1.49,-.8,;1.17,-.8,;1.17,-2.34,;-.16,-3.11,;-1.49,-2.32,;-2.82,-3.09,;-4.15,-2.32,;-2.82,-4.63,;-1.49,-5.4,;-.16,-4.63,;1.19,-5.4,;2.4,-6.1,;1.45,-6.98,;2.68,-4.83,)| Show InChI InChI=1S/C27H22F5N3O2/c1-16-24(20-9-5-6-10-22(20)29)25(36)35(15-23(33)17-7-3-2-4-8-17)26(37)34(16)14-18-13-19(28)11-12-21(18)27(30,31)32/h2-13,23H,14-15,33H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair