BDBM50163903 CHEMBL180819::N-{4-[3-(4-Fluoro-phenoxy)-1H-indol-5-yloxy]-3,5-bis-trifluoromethyl-phenyl}-oxalamic acid ethyl ester

SMILES: CCOC(=O)C(=O)Nc1cc(c(Oc2ccc3[nH]cc(Oc4ccc(F)cc4)c3c2)c(c1)C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=CKBXMCXLZQCZRG-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163903   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thyroid Hormone Receptor (TR-alpha)/(TR-beta) (Homo sapiens (Human))	BDBM50163903 (CHEMBL180819 | N-{4-[3-(4-Fluoro-phenoxy)-1H-indol...) Show SMILES CCOC(=O)C(=O)Nc1cc(c(Oc2ccc3[nH]cc(Oc4ccc(F)cc4)c3c2)c(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H17F7N2O5/c1-2-38-24(37)23(36)35-14-9-18(25(28,29)30)22(19(10-14)26(31,32)33)40-16-7-8-20-17(11-16)21(12-34-20)39-15-5-3-13(27)4-6-15/h3-12,34H,2H2,1H3,(H,35,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	495	n/a	n/a	n/a	n/a
BAYER HealthCare AG Curated by ChEMBL					Assay Description Agonist activity towards thyroid hormone receptor expressed in human HepG2 cells				Bioorg Med Chem Lett 15: 1835-40 (2005) Article DOI: 10.1016/j.bmcl.2005.02.028 BindingDB Entry DOI: 10.7270/Q290239F
					More data for this Ligand-Target Pair