BDBM50164249 1-[4-(3-Cyano-phenyl)-4-methyl-cyclohexyl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea::CHEMBL191388
SMILES: C[C@@]1(CC[C@@H](CC1)N(CCN1CC[C@@H](O)C1)C(=O)Nc1ccc(F)c(c1)C(F)(F)F)c1cccc(c1)C#N
InChI Key: InChIKey=IYUIEIUSJIXZIL-AZSVPQILSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanin-concentrating hormone receptor (Homo sapiens (Human)) | BDBM50164249 (1-[4-(3-Cyano-phenyl)-4-methyl-cyclohexyl]-3-(4-fl...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 391 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Inhibition constant for human Melanin concentrating hormone receptor 1 | J Med Chem 48: 2274-7 (2005) Article DOI: 10.1021/jm049035q BindingDB Entry DOI: 10.7270/Q2GH9HG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GPR145 (Homo sapiens (Human)) | BDBM50164249 (1-[4-(3-Cyano-phenyl)-4-methyl-cyclohexyl]-3-(4-fl...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Inhibition constant for human Melanin concentrating hormone receptor 2 | J Med Chem 48: 2274-7 (2005) Article DOI: 10.1021/jm049035q BindingDB Entry DOI: 10.7270/Q2GH9HG1 | |||||||||||
More data for this Ligand-Target Pair |