BDBM50164424 3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isochroman-1-one::3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one::CHEMBL192359

SMILES: CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1

InChI Key: InChIKey=HIVBATDUVFEJFZ-UHFFFAOYSA-N

Data: 7 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50164424   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50164424 (3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isoc...) Show SMILES CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Università di Napoli Federico II Curated by ChEMBL					Assay Description Agonist activity for human Urotensin 2 receptor				J Med Chem 48: 2480-92 (2005) Article DOI: 10.1021/jm049110x BindingDB Entry DOI: 10.7270/Q2ZK5G53
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50164424 (3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isoc...) Show SMILES CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Agonist activity at human urotensin 2 expressed in CHO cells by FLIPR				J Med Chem 53: 2695-708 (2010) Article DOI: 10.1021/jm901294u BindingDB Entry DOI: 10.7270/Q20G3K9N
					More data for this Ligand-Target Pair
Urotensin-2 (Homo sapiens (Human))	BDBM50164424 (3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isoc...) Show SMILES CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Agonist activity against human urotensin 2 receptor expressed in human NIH373 cells assessed as beta-galactosidase activity after 5 days by R-SAT ass...				Bioorg Med Chem 18: 4844-54 (2011) Article DOI: 10.1016/j.bmc.2010.04.041 BindingDB Entry DOI: 10.7270/Q2PG1SZ3
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50164424 (3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isoc...) Show SMILES CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Potency against human Urotensin 2 receptor				J Med Chem 45: 4950-3 (2002) Article DOI: 10.1021/jm025551+ BindingDB Entry DOI: 10.7270/Q22J6FK1
					More data for this Ligand-Target Pair
Urotensin-2 receptor (RAT)	BDBM50164424 (3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isoc...) Show SMILES CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Potency against rat Urotensin 2 receptor				J Med Chem 45: 4950-3 (2002) Article DOI: 10.1021/jm025551+ BindingDB Entry DOI: 10.7270/Q22J6FK1
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50164424 (3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isoc...) Show SMILES CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	316	n/a	n/a	n/a	n/a
ACADIA Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Potency against human Urotensin 2 receptor				J Med Chem 45: 4950-3 (2002) Article DOI: 10.1021/jm025551+ BindingDB Entry DOI: 10.7270/Q22J6FK1
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50164424 (3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isoc...) Show SMILES CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a
G£teborg University Curated by ChEMBL					Assay Description Activity against human urotensin-2 receptor expressed in NIH3T3 cells				J Med Chem 49: 2232-40 (2006) Article DOI: 10.1021/jm051121i BindingDB Entry DOI: 10.7270/Q24Q7XQB
					More data for this Ligand-Target Pair