BDBM50165719 CHEMBL3797331

SMILES: CCC[C@H]1N(CCC[C@@]1(Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)Oc1ccncc1)C(=O)c1cnccc1C(F)(F)F

InChI Key: InChIKey=PNVVGRQEJCGHJR-RFCYWSMNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50165719   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50165719 (CHEMBL3797331) Show SMILES CCC[C@H]1N(CCC[C@@]1(Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)Oc1ccncc1)C(=O)c1cnccc1C(F)(F)F |r| Show InChI InChI=1S/C16H18N2O6/c19-8-12-13(20)14(21)15(22)16(23-12)24-17-7-10-6-5-9-3-1-2-4-11(9)18-10/h1-7,12-16,19-22H,8H2/b17-7+/t12?,13?,14-,15?,16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assay				Bioorg Med Chem Lett 26: 2735-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.078 BindingDB Entry DOI: 10.7270/Q28S4RTD
					More data for this Ligand-Target Pair