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SMILES: CCC[C@H]1N(CCC[C@@]1(Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)Oc1ccccc1Cl)C(=O)c1cnccc1C(F)(F)F

InChI Key: InChIKey=NEGGDCWUVQDYLQ-OKTAIQBRSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50165727   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50165727
PNG
(CHEMBL3800119)
Show SMILES CCC[C@H]1N(CCC[C@@]1(Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)Oc1ccccc1Cl)C(=O)c1cnccc1C(F)(F)F |r|
Show InChI InChI=1S/C8H15NO6/c1-2-9-15-8-7(13)6(12)5(11)4(3-10)14-8/h2,4-8,10-13H,3H2,1H3/b9-2+/t4?,5?,6-,7?,8-/m0/s1
PDB
MMDB

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Similars
Article
PubMed
n/an/a 2.76E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assay

Bioorg Med Chem Lett 26: 2735-8 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.078
BindingDB Entry DOI: 10.7270/Q28S4RTD
More data for this
Ligand-Target Pair