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SMILES: COc1cc2ncnc(Nc3cccc4cn[nH]c34)c2cc1OC

InChI Key: InChIKey=YYVINMNNFSLSDT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50165889   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))		BDBM50165889
PNG
(CHEMBL3797215)
Show SMILES COc1cc2ncnc(Nc3cccc4cn[nH]c34)c2cc1OC
Show InChI InChI=1S/C17H15N5O2/c1-23-14-6-11-13(7-15(14)24-2)18-9-19-17(11)21-12-5-3-4-10-8-20-22-16(10)12/h3-9H,1-2H3,(H,20,22)(H,18,19,21)
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Article
PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...

Bioorg Med Chem Lett 26: 2724-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.100
BindingDB Entry DOI: 10.7270/Q2WM1G93
More data for this
Ligand-Target Pair