null

SMILES: Cc1nnc(Sc2sc(-c3cc[nH]n3)c3CC(C)(C)CC(=O)c23)s1

InChI Key: InChIKey=UMLABNGOXIVXOZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50165989   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50165989 (CHEMBL3799442) Show SMILES Cc1nnc(Sc2sc(-c3cc[nH]n3)c3CC(C)(C)CC(=O)c23)s1 Show InChI InChI=1S/C16H16N4OS3/c1-8-18-20-15(22-8)24-14-12-9(6-16(2,3)7-11(12)21)13(23-14)10-4-5-17-19-10/h4-5H,6-7H2,1-3H3,(H,17,19)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	993	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant wild type LRRK2 using fluorescein- ERM as substrate after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 26: 2631-5 (2016) Article DOI: 10.1016/j.bmcl.2016.04.021 BindingDB Entry DOI: 10.7270/Q2RV0QKC
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50165989 (CHEMBL3799442) Show SMILES Cc1nnc(Sc2sc(-c3cc[nH]n3)c3CC(C)(C)CC(=O)c23)s1 Show InChI InChI=1S/C16H16N4OS3/c1-8-18-20-15(22-8)24-14-12-9(6-16(2,3)7-11(12)21)13(23-14)10-4-5-17-19-10/h4-5H,6-7H2,1-3H3,(H,17,19)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.99E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant LRRK2 G2019S mutant using fluorescein- ERM as substrate after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 26: 2631-5 (2016) Article DOI: 10.1016/j.bmcl.2016.04.021 BindingDB Entry DOI: 10.7270/Q2RV0QKC
					More data for this Ligand-Target Pair