BDBM50166460 3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-chloro-4-trifluoromethyl-phenyl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione::CHEMBL189964

SMILES: N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccc(cc1Cl)C(F)(F)F)c1ccccc1

InChI Key: InChIKey=KYZDFCRRAMNNJS-QHCPKHFHSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50166460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50166460 (3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-chloro-4-trifl...) Show SMILES N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccc(cc1Cl)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C27H19ClF7N3O2/c28-21-11-16(26(30,31)32)9-10-17(21)18-12-37(13-19-20(27(33,34)35)7-4-8-22(19)29)25(40)38(24(18)39)14-23(36)15-5-2-1-3-6-15/h1-12,23H,13-14,36H2/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin-releasing hormone receptor (GNRHR) using GnRH peptide as radioligand				Bioorg Med Chem Lett 15: 2519-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.057 BindingDB Entry DOI: 10.7270/Q2M044ZX
					More data for this Ligand-Target Pair