BDBM50169643 8-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-sulfonyl]-phenyl}-6-methyl-3H-imidazo[1,5-a][1,3,5]triazin-4-one::CHEMBL183150

SMILES: CCOc1ccc(cc1-c1nc2c(nc(C)n2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1

InChI Key: InChIKey=OIQLBVLVMHTKBC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50169643   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50169643 (8-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...) Show SMILES CCOc1ccc(cc1-c1nc2c(nc(C)n2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1 Show InChI InChI=1S/C25H34N6O5S/c1-3-36-21-9-8-19(37(34,35)30-12-10-29(11-13-30)14-15-32)16-20(21)23-27-24-22(18-6-4-5-7-18)26-17(2)31(24)25(33)28-23/h8-9,16,18,32H,3-7,10-15H2,1-2H3,(H,27,28,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER HealthCare AG Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 1				Bioorg Med Chem Lett 15: 3900-7 (2005) Article DOI: 10.1016/j.bmcl.2005.05.090 BindingDB Entry DOI: 10.7270/Q2XS5TWD
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50169643 (8-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...) Show SMILES CCOc1ccc(cc1-c1nc2c(nc(C)n2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1 Show InChI InChI=1S/C25H34N6O5S/c1-3-36-21-9-8-19(37(34,35)30-12-10-29(11-13-30)14-15-32)16-20(21)23-27-24-22(18-6-4-5-7-18)26-17(2)31(24)25(33)28-23/h8-9,16,18,32H,3-7,10-15H2,1-2H3,(H,27,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER HealthCare AG Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5				Bioorg Med Chem Lett 15: 3900-7 (2005) Article DOI: 10.1016/j.bmcl.2005.05.090 BindingDB Entry DOI: 10.7270/Q2XS5TWD
					More data for this Ligand-Target Pair