BDBM50172878 (S)-2-{3-[4-(3-Dimethylamino-propyl)-piperazin-1-yl]-propyl}-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione::CHEMBL195677

SMILES: CN(C)CCCN1CCN(CCCn2c(O)c3Cc4ccccc4Cn3c2=O)CC1

InChI Key: InChIKey=JMEPVEFSAGGAPH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50172878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50172878 ((S)-2-{3-[4-(3-Dimethylamino-propyl)-piperazin-1-y...) Show SMILES CN(C)CCCN1CCN(CCCn2c(O)c3Cc4ccccc4Cn3c2=O)CC1 Show InChI InChI=1S/C23H35N5O2/c1-24(2)9-5-10-25-13-15-26(16-14-25)11-6-12-27-22(29)21-17-19-7-3-4-8-20(19)18-28(21)23(27)30/h3-4,7-8,29H,5-6,9-18H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	7.5	n/a
Université de Lille II Curated by ChEMBL					Assay Description Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...				Bioorg Med Chem Lett 15: 4828-32 (2005) Article DOI: 10.1016/j.bmcl.2005.07.039 BindingDB Entry DOI: 10.7270/Q2TD9WW1
					More data for this Ligand-Target Pair