BDBM50173015 CHEMBL196422::N-tert-Butyl-4-{4-[4-(chloro-difluoro-methoxy)-phenylamino]-phthalazin-1-yl}-benzamide::N-tert-butyl-4-(4-(4-(chlorodifluoromethoxy)phenylamino)phthalazin-1-yl)benzamide

SMILES: CC(C)(C)NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12

InChI Key: InChIKey=YALIPFXTGXTMIM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50173015   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50173015 (CHEMBL196422 | N-tert-Butyl-4-{4-[4-(chloro-difluo...) Show SMILES CC(C)(C)NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C26H23ClF2N4O2/c1-25(2,3)31-24(34)17-10-8-16(9-11-17)22-20-6-4-5-7-21(20)23(33-32-22)30-18-12-14-19(15-13-18)35-26(27,28)29/h4-15H,1-3H3,(H,30,33)(H,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
ImClone Systems, Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) by HTRF method				Bioorg Med Chem 17: 731-40 (2009) Article DOI: 10.1016/j.bmc.2008.11.049 BindingDB Entry DOI: 10.7270/Q2W95929
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50173015 (CHEMBL196422 | N-tert-Butyl-4-{4-[4-(chloro-difluo...) Show SMILES CC(C)(C)NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C26H23ClF2N4O2/c1-25(2,3)31-24(34)17-10-8-16(9-11-17)22-20-6-4-5-7-21(20)23(33-32-22)30-18-12-14-19(15-13-18)35-26(27,28)29/h4-15H,1-3H3,(H,30,33)(H,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
ImClone Systems Curated by ChEMBL					Assay Description Inhibition of Vascular endothelial growth factor receptor 2 kinase phosphorylation of pGAT-biotin peptide				Bioorg Med Chem Lett 15: 4696-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.064 BindingDB Entry DOI: 10.7270/Q25Q4VNS
					More data for this Ligand-Target Pair