BDBM50173120 CHEMBL3810070

SMILES: CC(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)[nH]n2)no1

InChI Key: InChIKey=RUAXPITVQTVSAL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173120   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50173120 (CHEMBL3810070) Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)[nH]n2)no1 Show InChI InChI=1S/C29H34N8O3/c1-19(2)25-17-27(35-40-25)32-29(39)30-23-10-8-21(9-11-23)24-16-26(34-33-24)31-28(38)22-6-4-20(5-7-22)18-37-14-12-36(3)13-15-37/h4-11,16-17,19H,12-15,18H2,1-3H3,(H2,30,32,35,39)(H2,31,33,34,38)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	855	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human ALK (1084 to 1410 residues) expressed in baculovirus infected Sf21 insect cells using polyGlu4:Tyr peptide as substrate after 1 h...				J Med Chem 59: 3906-19 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B2G
					More data for this Ligand-Target Pair