BDBM50173144 4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenylcarbamoyl]-2,5-dihydro-furan-3-carboxylic acid::CHEMBL193371

SMILES: OC(=O)C1=C(COC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1

InChI Key: InChIKey=GOGSHDUZMWCNCO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50173144   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM50173144 (4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...) Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C19H14Cl2FNO5/c20-14-2-1-3-16(22)13(14)9-28-17-5-4-10(6-15(17)21)23-18(24)11-7-27-8-12(11)19(25)26/h1-6H,7-9H2,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
4SC AG Curated by ChEMBL					Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay				Bioorg Med Chem Lett 15: 4854-7 (2005) Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat))	BDBM50173144 (4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...) Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C19H14Cl2FNO5/c20-14-2-1-3-16(22)13(14)9-28-17-5-4-10(6-15(17)21)23-18(24)11-7-27-8-12(11)19(25)26/h1-6H,7-9H2,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
4SC AG Curated by ChEMBL					Assay Description Inhibitory activity against rat dihydroorotate dehydrogenase				Bioorg Med Chem Lett 15: 4854-7 (2005) Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Mus musculus)	BDBM50173144 (4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...) Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C19H14Cl2FNO5/c20-14-2-1-3-16(22)13(14)9-28-17-5-4-10(6-15(17)21)23-18(24)11-7-27-8-12(11)19(25)26/h1-6H,7-9H2,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
4SC AG Curated by ChEMBL					Assay Description Inhibitory activity against mouse dihydroorotate dehydrogenase				Bioorg Med Chem Lett 15: 4854-7 (2005) Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N
					More data for this Ligand-Target Pair