BDBM50173147 2-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid::CHEMBL196256

SMILES: COc1cccc(c1)-c1ccc(NC(=O)C2=C(CCC2O)C(O)=O)c(F)c1

InChI Key: InChIKey=BZUKHWIVKMDFFY-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (Homo sapiens (Human))	BDBM50173147 (2-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-3-h...) Show SMILES COc1cccc(c1)-c1ccc(NC(=O)C2=C(CCC2O)C(O)=O)c(F)c1 |t:16| Show InChI InChI=1S/C20H18FNO5/c1-27-13-4-2-3-11(9-13)12-5-7-16(15(21)10-12)22-19(24)18-14(20(25)26)6-8-17(18)23/h2-5,7,9-10,17,23H,6,8H2,1H3,(H,22,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
4SC AG Curated by ChEMBL					Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay				Bioorg Med Chem Lett 15: 4854-7 (2005) Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N
					More data for this Ligand-Target Pair