BDBM50173633 CHEMBL194201::N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide

SMILES: CCc1nc(c(s1)-c1ccnc(NC(=O)CCc2ccccc2)c1)-c1cccc(C)c1

InChI Key: InChIKey=XLMIKSYZFWHWMU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173633   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50173633 (CHEMBL194201 | N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-y...) Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)CCc2ccccc2)c1)-c1cccc(C)c1 Show InChI InChI=1S/C26H25N3OS/c1-3-24-29-25(20-11-7-8-18(2)16-20)26(31-24)21-14-15-27-22(17-21)28-23(30)13-12-19-9-5-4-6-10-19/h4-11,14-17H,3,12-13H2,1-2H3,(H,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha				J Med Chem 48: 5966-79 (2005) Article DOI: 10.1021/jm050165o BindingDB Entry DOI: 10.7270/Q2G160DZ
					More data for this Ligand-Target Pair