BDBM50173635 4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-2-pyrrolidin-1-yl-pyridine::CHEMBL370405

SMILES: CCc1nc(c(s1)-c1ccnc(c1)N1CCCC1)-c1cccc(C)c1

InChI Key: InChIKey=COPUEWHBPUCYBW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173635   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50173635 (4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-2-pyrrolidin-1-...) Show SMILES CCc1nc(c(s1)-c1ccnc(c1)N1CCCC1)-c1cccc(C)c1 Show InChI InChI=1S/C21H23N3S/c1-3-19-23-20(16-8-6-7-15(2)13-16)21(25-19)17-9-10-22-18(14-17)24-11-4-5-12-24/h6-10,13-14H,3-5,11-12H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha				J Med Chem 48: 5966-79 (2005) Article DOI: 10.1021/jm050165o BindingDB Entry DOI: 10.7270/Q2G160DZ
					More data for this Ligand-Target Pair