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SMILES: Fc1ccc(CN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3n2)cc1

InChI Key: InChIKey=POQMRAAOGZQAAM-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175392   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50175392
PNG
(CHEMBL371010 | N-((4-(4-cyanobenzyl)-4H-1,2,4-tria...)
Show SMILES Fc1ccc(CN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C28H21FN6O/c29-24-12-9-22(10-13-24)16-34(28(36)26-14-11-23-3-1-2-4-25(23)32-26)18-27-33-31-19-35(27)17-21-7-5-20(15-30)6-8-21/h1-14,19H,16-18H2
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n/an/a 5n/an/an/an/an/an/a



Janssen Research Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity against K-Ras farnesyl transferase

Bioorg Med Chem Lett 15: 5407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.007
BindingDB Entry DOI: 10.7270/Q2S18239
More data for this
Ligand-Target Pair