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SMILES: Fc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3n2)cc1

InChI Key: InChIKey=XCXMUQZTMJHHML-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175394   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50175394
PNG
(CHEMBL200193 | N-((4-(4-cyanobenzyl)-4H-1,2,4-tria...)
Show SMILES Fc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C29H23FN6O/c30-25-12-9-21(10-13-25)15-16-35(29(37)27-14-11-24-3-1-2-4-26(24)33-27)19-28-34-32-20-36(28)18-23-7-5-22(17-31)6-8-23/h1-14,20H,15-16,18-19H2
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n/an/a 19n/an/an/an/an/an/a



Janssen Research Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity against K-Ras farnesyl transferase

Bioorg Med Chem Lett 15: 5407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.007
BindingDB Entry DOI: 10.7270/Q2S18239
More data for this
Ligand-Target Pair