BDBM50175398 CHEMBL381432::N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)furan-2-carboxamide

SMILES: Brc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccco2)cc1

InChI Key: InChIKey=YSWNHCXNSHYSNK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175398   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50175398 (CHEMBL381432 | N-(4-bromophenethyl)-N-((4-(4-cyano...) Show SMILES Brc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccco2)cc1 Show InChI InChI=1S/C24H20BrN5O2/c25-21-9-7-18(8-10-21)11-12-29(24(31)22-2-1-13-32-22)16-23-28-27-17-30(23)15-20-5-3-19(14-26)4-6-20/h1-10,13,17H,11-12,15-16H2	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	99.3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity against K-Ras farnesyl transferase				Bioorg Med Chem Lett 15: 5407-11 (2005) Article DOI: 10.1016/j.bmcl.2005.09.007 BindingDB Entry DOI: 10.7270/Q2S18239
					More data for this Ligand-Target Pair