BDBM50175399 CHEMBL199365::N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-methoxyphenethyl)quinoline-2-carboxamide

SMILES: COc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3n2)cc1

InChI Key: InChIKey=YZPAXNOIBXSUQJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175399   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50175399 (CHEMBL199365 | N-((4-(4-cyanobenzyl)-4H-1,2,4-tria...) Show SMILES COc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3n2)cc1 Show InChI InChI=1S/C30H26N6O2/c1-38-26-13-10-22(11-14-26)16-17-35(30(37)28-15-12-25-4-2-3-5-27(25)33-28)20-29-34-32-21-36(29)19-24-8-6-23(18-31)7-9-24/h2-15,21H,16-17,19-20H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity against K-Ras farnesyl transferase				Bioorg Med Chem Lett 15: 5407-11 (2005) Article DOI: 10.1016/j.bmcl.2005.09.007 BindingDB Entry DOI: 10.7270/Q2S18239
					More data for this Ligand-Target Pair