BindingDB logo
myBDB logout

null

SMILES: Brc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3c2)cc1

InChI Key: InChIKey=GILIRUXJPMYMKB-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175403   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50175403
PNG
(CHEMBL201299 | N-(4-bromophenethyl)-N-((4-(4-cyano...)
Show SMILES Brc1ccc(CCN(Cc2nncn2Cc2ccc(cc2)C#N)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C30H24BrN5O/c31-28-13-9-22(10-14-28)15-16-35(30(37)27-12-11-25-3-1-2-4-26(25)17-27)20-29-34-33-21-36(29)19-24-7-5-23(18-32)6-8-24/h1-14,17,21H,15-16,19-20H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 28.3n/an/an/an/an/an/a



Janssen Research Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity against K-Ras farnesyl transferase

Bioorg Med Chem Lett 15: 5407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.007
BindingDB Entry DOI: 10.7270/Q2S18239
More data for this
Ligand-Target Pair