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SMILES: COc1cc(nc2ccccc12)C(=O)N(CCc1ccc(Br)cc1)Cc1nncn1Cc1ccc(cc1)C#N

InChI Key: InChIKey=ADZRJKLOXYZNBT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175409   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50175409
PNG
(CHEMBL426837 | N-(4-bromophenethyl)-N-((4-(4-cyano...)
Show SMILES COc1cc(nc2ccccc12)C(=O)N(CCc1ccc(Br)cc1)Cc1nncn1Cc1ccc(cc1)C#N
Show InChI InChI=1S/C30H25BrN6O2/c1-39-28-16-27(34-26-5-3-2-4-25(26)28)30(38)36(15-14-21-10-12-24(31)13-11-21)19-29-35-33-20-37(29)18-23-8-6-22(17-32)7-9-23/h2-13,16,20H,14-15,18-19H2,1H3
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Article
PubMed
n/an/a 96.5n/an/an/an/an/an/a



Janssen Research Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity against K-Ras farnesyl transferase

Bioorg Med Chem Lett 15: 5407-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.007
BindingDB Entry DOI: 10.7270/Q2S18239
More data for this
Ligand-Target Pair