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BDBM50176090 4-[4-(3-Ethyl-4-methyl-phenylamino)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyric acid ethyl ester::CHEMBL198822

SMILES: CCOC(=O)CCCn1c(=O)cc(Nc2ccc(C)c(CC)c2)[nH]c1=O

InChI Key: InChIKey=RNCDLWHHNPWWJZ-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50176090   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA polymerase IIIC


(Bacillus subtilis)		BDBM50176090
PNG
(4-[4-(3-Ethyl-4-methyl-phenylamino)-2,6-dioxo-3,6-...)
Show SMILES CCOC(=O)CCCn1c(=O)cc(Nc2ccc(C)c(CC)c2)[nH]c1=O
Show InChI InChI=1S/C19H25N3O4/c1-4-14-11-15(9-8-13(14)3)20-16-12-17(23)22(19(25)21-16)10-6-7-18(24)26-5-2/h8-9,11-12,20H,4-7,10H2,1-3H3,(H,21,25)
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC sid
UniChem

Similars
Article
PubMed
 100n/an/an/an/an/an/an/an/a



GLSynthesis Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]dTMP 250 pM (30 degree C for 10 min)

J Med Chem 48: 7063-74 (2005)


Article DOI: 10.1021/jm050517r
BindingDB Entry DOI: 10.7270/Q2W66MJN
More data for this
Ligand-Target Pair