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BDBM50176109 6-(3-Ethyl-4-methyl-phenylamino)-3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl}-1H-pyrimidine-2,4-dione::CHEMBL197697

SMILES: CCc1cc(Nc2cc(=O)n(CCOCCOCCO)c(=O)[nH]2)ccc1C

InChI Key: InChIKey=XPRBJQVCBNNCJM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50176109   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA polymerase IIIC


(Bacillus subtilis)		BDBM50176109
PNG
(6-(3-Ethyl-4-methyl-phenylamino)-3-{2-[2-(2-hydrox...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCOCCOCCO)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C19H27N3O5/c1-3-15-12-16(5-4-14(15)2)20-17-13-18(24)22(19(25)21-17)6-8-26-10-11-27-9-7-23/h4-5,12-13,20,23H,3,6-11H2,1-2H3,(H,21,25)
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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Article
PubMed
 87n/an/an/an/an/an/an/an/a



GLSynthesis Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]dTMP 250 pM (30 degree C for 10 min)

J Med Chem 48: 7063-74 (2005)


Article DOI: 10.1021/jm050517r
BindingDB Entry DOI: 10.7270/Q2W66MJN
More data for this
Ligand-Target Pair