BDBM50176567 2-morpholinoethyl 3-cyano-4-(4-(2-methoxyphenoxy)phenylamino)-5-methylH-pyrrolo[1,2-b]pyridazin-6-ylcarbamate::CHEMBL265786

SMILES: COc1ccccc1Oc1ccc(Nc2c(cnn3cc(NC(=O)OCCN4CCOCC4)c(C)c23)C#N)cc1

InChI Key: InChIKey=LTVZJIAYZPHDRB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50176567   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50176567 (2-morpholinoethyl 3-cyano-4-(4-(2-methoxyphenoxy)p...) Show SMILES COc1ccccc1Oc1ccc(Nc2c(cnn3cc(NC(=O)OCCN4CCOCC4)c(C)c23)C#N)cc1 Show InChI InChI=1S/C29H30N6O5/c1-20-24(33-29(36)39-16-13-34-11-14-38-15-12-34)19-35-28(20)27(21(17-30)18-31-35)32-22-7-9-23(10-8-22)40-26-6-4-3-5-25(26)37-2/h3-10,18-19,32H,11-16H2,1-2H3,(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against MEK				Bioorg Med Chem Lett 16: 628-32 (2005) Article DOI: 10.1016/j.bmcl.2005.10.052 BindingDB Entry DOI: 10.7270/Q2J67GHT
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