BDBM50177066 3-(4-Cyclopropyl-phenyl)-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one::9-dimethylamino-3-(4-cyclopropylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one::CHEMBL387687

SMILES: CN(C)c1ccnc2sc3c(ncn(-c4ccc(cc4)C4CC4)c3=O)c12

InChI Key: InChIKey=KPZFXWLIJHOOKE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177066   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50177066 (3-(4-Cyclopropyl-phenyl)-9-dimethylamino-3H-pyrido...) Show SMILES CN(C)c1ccnc2sc3c(ncn(-c4ccc(cc4)C4CC4)c3=O)c12 Show InChI InChI=1S/C20H18N4OS/c1-23(2)15-9-10-21-19-16(15)17-18(26-19)20(25)24(11-22-17)14-7-5-13(6-8-14)12-3-4-12/h5-12H,3-4H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization				J Med Chem 48: 7374-88 (2005) Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50177066 (3-(4-Cyclopropyl-phenyl)-9-dimethylamino-3H-pyrido...) Show SMILES CN(C)c1ccnc2sc3c(ncn(-c4ccc(cc4)C4CC4)c3=O)c12 Show InChI InChI=1S/C20H18N4OS/c1-23(2)15-9-10-21-19-16(15)17-18(26-19)20(25)24(11-22-17)14-7-5-13(6-8-14)12-3-4-12/h5-12H,3-4H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Biocampus Curated by ChEMBL					Assay Description Inhibition of rat mGluR1				Eur J Med Chem 43: 1025-34 (2008) Article DOI: 10.1016/j.ejmech.2007.06.024 BindingDB Entry DOI: 10.7270/Q2V987VM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50177066 (3-(4-Cyclopropyl-phenyl)-9-dimethylamino-3H-pyrido...) Show SMILES CN(C)c1ccnc2sc3c(ncn(-c4ccc(cc4)C4CC4)c3=O)c12 Show InChI InChI=1S/C20H18N4OS/c1-23(2)15-9-10-21-19-16(15)17-18(26-19)20(25)24(11-22-17)14-7-5-13(6-8-14)12-3-4-12/h5-12H,3-4H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization				J Med Chem 48: 7374-88 (2005) Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0
					More data for this Ligand-Target Pair