BDBM50177073 2-Butyl-9-dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one::9-dimethylamino-2-n-butyl-3H-5-thia-1,3,6-triazafluoren-4-one::CHEMBL387976

SMILES: CCCCc1nc2c(sc3nccc(N(C)C)c23)c(=O)n1-c1ccc(CC)cc1

InChI Key: InChIKey=VYUFFNORDHWOJK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177073   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50177073 (2-Butyl-9-dimethylamino-3-(4-ethyl-phenyl)-3H-pyri...) Show SMILES CCCCc1nc2c(sc3nccc(N(C)C)c23)c(=O)n1-c1ccc(CC)cc1 Show InChI InChI=1S/C23H26N4OS/c1-5-7-8-18-25-20-19-17(26(3)4)13-14-24-22(19)29-21(20)23(28)27(18)16-11-9-15(6-2)10-12-16/h9-14H,5-8H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization				J Med Chem 48: 7374-88 (2005) Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50177073 (2-Butyl-9-dimethylamino-3-(4-ethyl-phenyl)-3H-pyri...) Show SMILES CCCCc1nc2c(sc3nccc(N(C)C)c23)c(=O)n1-c1ccc(CC)cc1 Show InChI InChI=1S/C23H26N4OS/c1-5-7-8-18-25-20-19-17(26(3)4)13-14-24-22(19)29-21(20)23(28)27(18)16-11-9-15(6-2)10-12-16/h9-14H,5-8H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
Biocampus Curated by ChEMBL					Assay Description Inhibition of rat mGluR1				Eur J Med Chem 43: 1025-34 (2008) Article DOI: 10.1016/j.ejmech.2007.06.024 BindingDB Entry DOI: 10.7270/Q2V987VM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50177073 (2-Butyl-9-dimethylamino-3-(4-ethyl-phenyl)-3H-pyri...) Show SMILES CCCCc1nc2c(sc3nccc(N(C)C)c23)c(=O)n1-c1ccc(CC)cc1 Show InChI InChI=1S/C23H26N4OS/c1-5-7-8-18-25-20-19-17(26(3)4)13-14-24-22(19)29-21(20)23(28)27(18)16-11-9-15(6-2)10-12-16/h9-14H,5-8H2,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	901	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization				J Med Chem 48: 7374-88 (2005) Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0
					More data for this Ligand-Target Pair