BDBM50178781 CHEMBL171145::N-(2-amino-2-oxoethyl)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

SMILES: NC(=O)CNC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21

InChI Key: InChIKey=ZAAGFGBXXRJPBY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50178781   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human))	BDBM50178781 (CHEMBL171145 | N-(2-amino-2-oxoethyl)-6-chloro-2,3...) Show SMILES NC(=O)CNC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21 Show InChI InChI=1S/C15H16ClN3O2/c16-8-4-5-12-11(6-8)9-2-1-3-10(14(9)19-12)15(21)18-7-13(17)20/h4-6,10,19H,1-3,7H2,(H2,17,20)(H,18,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Elixir Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay				J Med Chem 48: 8045-54 (2005) Article DOI: 10.1021/jm050522v BindingDB Entry DOI: 10.7270/Q27D2TPK
					More data for this Ligand-Target Pair