BDBM50179137 (R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::CHEMBL265985

SMILES: Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1

InChI Key: InChIKey=NTMXDNFEFWCVSA-LOYHVIPDSA-N

Data: 4 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50179137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 5 (Homo sapiens (Human))	BDBM50179137 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C34H43ClN4O4/c35-28-12-10-24(11-13-28)20-30(37-31(40)29-21-25-6-4-5-7-26(25)22-36-29)32(41)38-16-14-34(15-17-38,27-8-2-1-3-9-27)23-39-18-19-43-33(39)42/h4-7,10-13,27,29-30,36H,1-3,8-9,14-23H2,(H,37,40)/t29-,30-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50179137 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C34H43ClN4O4/c35-28-12-10-24(11-13-28)20-30(37-31(40)29-21-25-6-4-5-7-26(25)22-36-29)32(41)38-16-14-34(15-17-38,27-8-2-1-3-9-27)23-39-18-19-43-33(39)42/h4-7,10-13,27,29-30,36H,1-3,8-9,14-23H2,(H,37,40)/t29-,30-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.80	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC4R by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50179137 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C34H43ClN4O4/c35-28-12-10-24(11-13-28)20-30(37-31(40)29-21-25-6-4-5-7-26(25)22-36-29)32(41)38-16-14-34(15-17-38,27-8-2-1-3-9-27)23-39-18-19-43-33(39)42/h4-7,10-13,27,29-30,36H,1-3,8-9,14-23H2,(H,37,40)/t29-,30-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC1BR expressed in CHO cells				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50179137 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C34H43ClN4O4/c35-28-12-10-24(11-13-28)20-30(37-31(40)29-21-25-6-4-5-7-26(25)22-36-29)32(41)38-16-14-34(15-17-38,27-8-2-1-3-9-27)23-39-18-19-43-33(39)42/h4-7,10-13,27,29-30,36H,1-3,8-9,14-23H2,(H,37,40)/t29-,30-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC4R by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 5 (Homo sapiens (Human))	BDBM50179137 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C34H43ClN4O4/c35-28-12-10-24(11-13-28)20-30(37-31(40)29-21-25-6-4-5-7-26(25)22-36-29)32(41)38-16-14-34(15-17-38,27-8-2-1-3-9-27)23-39-18-19-43-33(39)42/h4-7,10-13,27,29-30,36H,1-3,8-9,14-23H2,(H,37,40)/t29-,30-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC5R by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50179137 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C34H43ClN4O4/c35-28-12-10-24(11-13-28)20-30(37-31(40)29-21-25-6-4-5-7-26(25)22-36-29)32(41)38-16-14-34(15-17-38,27-8-2-1-3-9-27)23-39-18-19-43-33(39)42/h4-7,10-13,27,29-30,36H,1-3,8-9,14-23H2,(H,37,40)/t29-,30-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC1BR by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50179137 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3CCOC3=O)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C34H43ClN4O4/c35-28-12-10-24(11-13-28)20-30(37-31(40)29-21-25-6-4-5-7-26(25)22-36-29)32(41)38-16-14-34(15-17-38,27-8-2-1-3-9-27)23-39-18-19-43-33(39)42/h4-7,10-13,27,29-30,36H,1-3,8-9,14-23H2,(H,37,40)/t29-,30-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair