BDBM50181680 6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-amide::CHEMBL197652

SMILES: CN1CCN(Cc2ccc(NC(=O)c3cc(c[nH]c3=O)-c3ccncc3)cc2)CC1

InChI Key: InChIKey=MGEAZGCEEMEQLI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50181680   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50181680 (6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carboxylic a...) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3cc(c[nH]c3=O)-c3ccncc3)cc2)CC1 Show InChI InChI=1S/C23H25N5O2/c1-27-10-12-28(13-11-27)16-17-2-4-20(5-3-17)26-23(30)21-14-19(15-25-22(21)29)18-6-8-24-9-7-18/h2-9,14-15H,10-13,16H2,1H3,(H,25,29)(H,26,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
ChemBridge Research Laboratories and ChemBridge Corporation Curated by ChEMBL					Assay Description Inhibitory activity against ALK				J Med Chem 49: 1006-15 (2006) Article DOI: 10.1021/jm050824x BindingDB Entry DOI: 10.7270/Q2H994T6
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50181680 (6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carboxylic a...) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3cc(c[nH]c3=O)-c3ccncc3)cc2)CC1 Show InChI InChI=1S/C23H25N5O2/c1-27-10-12-28(13-11-27)16-17-2-4-20(5-3-17)26-23(30)21-14-19(15-25-22(21)29)18-6-8-24-9-7-18/h2-9,14-15H,10-13,16H2,1H3,(H,25,29)(H,26,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
ChemBridge Research Laboratories and ChemBridge Corporation Curated by ChEMBL					Assay Description Inhibitory activity against IRK				J Med Chem 49: 1006-15 (2006) Article DOI: 10.1021/jm050824x BindingDB Entry DOI: 10.7270/Q2H994T6
					More data for this Ligand-Target Pair