BDBM50182706 4-chloro-6-(5-(hydroxymethyl)-4-(piperazin-1-yl)-1H-pyrazol-3-yl)benzene-1,3-diol::CHEMBL437306
SMILES: OCc1[nH]nc(c1N1CCNCC1)-c1cc(Cl)c(O)cc1O
InChI Key: InChIKey=FSKYEZLXSOXCQO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50182706 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Heat Shock Protein 90 (Hsp90)
(Homo sapiens (Human)) | BDBM50182706
(4-chloro-6-(5-(hydroxymethyl)-4-(piperazin-1-yl)-1...)Show InChI InChI=1S/C14H17ClN4O3/c15-9-5-8(11(21)6-12(9)22)13-14(10(7-20)17-18-13)19-3-1-16-2-4-19/h5-6,16,20-22H,1-4,7H2,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.22E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis Ltd
Curated by ChEMBL
| Assay Description Inhibition of HSP90 ATPase activity |
Bioorg Med Chem Lett 16: 2543-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.099 BindingDB Entry DOI: 10.7270/Q2G44PWS |
More data for this Ligand-Target Pair | |
Heat Shock Protein 90 (Hsp90)
(Homo sapiens (Human)) | BDBM50182706
(4-chloro-6-(5-(hydroxymethyl)-4-(piperazin-1-yl)-1...)Show InChI InChI=1S/C14H17ClN4O3/c15-9-5-8(11(21)6-12(9)22)13-14(10(7-20)17-18-13)19-3-1-16-2-4-19/h5-6,16,20-22H,1-4,7H2,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis Ltd
Curated by ChEMBL
| Assay Description Inhibition of HSP90 by FP assay |
Bioorg Med Chem Lett 16: 2543-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.099 BindingDB Entry DOI: 10.7270/Q2G44PWS |
More data for this Ligand-Target Pair | |