Found 5 hits for monomerid = 50183807 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50183807
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccccc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C26H24N2O3S/c1-26(2,32(3,30)31)21-16-19-11-8-14-27-24(19)23(17-21)18-9-7-10-20(15-18)25(29)28-22-12-5-4-6-13-22/h4-17H,1-3H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole blood |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50183807
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccccc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C26H24N2O3S/c1-26(2,32(3,30)31)21-16-19-11-8-14-27-24(19)23(17-21)18-9-7-10-20(15-18)25(29)28-22-12-5-4-6-13-22/h4-17H,1-3H3,(H,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4A |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Homo sapiens (Human)) | BDBM50183807
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccccc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C26H24N2O3S/c1-26(2,32(3,30)31)21-16-19-11-8-14-27-24(19)23(17-21)18-9-7-10-20(15-18)25(29)28-22-12-5-4-6-13-22/h4-17H,1-3H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4C |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50183807
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccccc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C26H24N2O3S/c1-26(2,32(3,30)31)21-16-19-11-8-14-27-24(19)23(17-21)18-9-7-10-20(15-18)25(29)28-22-12-5-4-6-13-22/h4-17H,1-3H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4B |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50183807
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccccc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C26H24N2O3S/c1-26(2,32(3,30)31)21-16-19-11-8-14-27-24(19)23(17-21)18-9-7-10-20(15-18)25(29)28-22-12-5-4-6-13-22/h4-17H,1-3H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4D |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |