BDBM50187642 CHEMBL378559::N-cyclopentanecarboxyl-1,3-diphenyl-5-amino-1H-pyrazole

SMILES: O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)C1CCCC1

InChI Key: InChIKey=LJDIFWDVXAVJKC-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50187642   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50187642 (CHEMBL378559 | N-cyclopentanecarboxyl-1,3-diphenyl...) Show SMILES O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)C1CCCC1 Show InChI InChI=1S/C21H21N3O/c25-21(17-11-7-8-12-17)22-20-15-19(16-9-3-1-4-10-16)23-24(20)18-13-5-2-6-14-18/h1-6,9-10,13-15,17H,7-8,11-12H2,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cells				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50187642 (CHEMBL378559 | N-cyclopentanecarboxyl-1,3-diphenyl...) Show SMILES O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)C1CCCC1 Show InChI InChI=1S/C21H21N3O/c25-21(17-11-7-8-12-17)22-20-15-19(16-9-3-1-4-10-16)23-24(20)18-13-5-2-6-14-18/h1-6,9-10,13-15,17H,7-8,11-12H2,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.41E+3	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair