BDBM50187859 4-(2,3-dihydro-1H-tetrazol-5-yl)-5-(3,5-dimethoxyphenylamino)isothiazol-3-ol::CHEMBL210072

SMILES: COc1cc(Nc2s[nH]c(=O)c2C2=NNNN2)cc(OC)c1

InChI Key: InChIKey=NPFCLSDFKLVLKN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50187859   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50187859 (4-(2,3-dihydro-1H-tetrazol-5-yl)-5-(3,5-dimethoxyp...) Show SMILES COc1cc(Nc2s[nH]c(=O)c2C2=NNNN2)cc(OC)c1 |t:13| Show InChI InChI=1S/C12H14N6O3S/c1-20-7-3-6(4-8(5-7)21-2)13-12-9(11(19)16-22-12)10-14-17-18-15-10/h3-5,13,17-18H,1-2H3,(H,14,15)(H,16,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Valeant Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of MEK1				Bioorg Med Chem Lett 16: 3975-80 (2006) Article DOI: 10.1016/j.bmcl.2006.05.019 BindingDB Entry DOI: 10.7270/Q2SJ1K6C
					More data for this Ligand-Target Pair