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BDBM50188085 1-(4-Fluorobenzyl)-1H-imidazole::CHEMBL377770

SMILES: Fc1ccc(Cn2ccnc2)cc1

InChI Key: InChIKey=LOHJXVMUYVDWOW-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50188085   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 1.84E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat microsomal 17,20-lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4011-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.070
BindingDB Entry DOI: 10.7270/Q27M07J2
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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PubMed
n/an/a 8.66E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat microsomal 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4011-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.070
BindingDB Entry DOI: 10.7270/Q27M07J2
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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Article
PubMed
n/an/a 9.65E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 330n/an/an/an/an/an/a



Eindhoven University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human CYP11B2 expressed in chinese hamster V79 cells


J Med Chem 53: 1712-25 (2010)


Article DOI: 10.1021/jm901356d
BindingDB Entry DOI: 10.7270/Q2XS5VGF
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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n/an/a 880n/an/an/an/an/an/a



University of the West of Scotland

Curated by ChEMBL


Assay Description
Inhibition of aromatase


Bioorg Med Chem Lett 19: 4698-701 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.070
BindingDB Entry DOI: 10.7270/Q29K4B72
More data for this
Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial


(Homo sapiens (Human))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
PDB

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Article
PubMed
n/an/a 494n/an/an/an/an/an/a



Eindhoven University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human CYP11B1 expressed in chinese hamster V79 cells


J Med Chem 53: 1712-25 (2010)


Article DOI: 10.1021/jm901356d
BindingDB Entry DOI: 10.7270/Q2XS5VGF
More data for this
Ligand-Target Pair
Cytochrome P450 17A1


(Rattus norvegicus (Rat))
BDBM50188085
PNG
(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Show SMILES Fc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C10H9FN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
KEGG

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CHEMBL
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PC sid
UniChem

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Article
PubMed
n/an/a 1.13E+4n/an/an/an/an/an/a



Kingston University

Curated by ChEMBL


Assay Description
Inhibition of rat testis 17,20 lyase component of P450-17alpha


Bioorg Med Chem Lett 16: 4752-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.092
BindingDB Entry DOI: 10.7270/Q2P55N43
More data for this
Ligand-Target Pair