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BDBM50188360 4-(4-fluoro-phenyl)-8-[2-(3-fluoro-phenyl)-2-hydroxy-cyclohexyl]-2,8-diaza-spiro[4.5]decan-1-one::CHEMBL379938

SMILES: OC1(CCCCC1N1CCC2(CC1)C(CNC2=O)c1ccc(F)cc1)c1cccc(F)c1

InChI Key: InChIKey=QLYGIDCUEOROKH-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50188360   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))		BDBM50188360
PNG
(4-(4-fluoro-phenyl)-8-[2-(3-fluoro-phenyl)-2-hydro...)
Show SMILES OC1(CCCCC1N1CCC2(CC1)C(CNC2=O)c1ccc(F)cc1)c1cccc(F)c1
Show InChI InChI=1S/C26H30F2N2O2/c27-20-9-7-18(8-10-20)22-17-29-24(31)25(22)12-14-30(15-13-25)23-6-1-2-11-26(23,32)19-4-3-5-21(28)16-19/h3-5,7-10,16,22-23,32H,1-2,6,11-15,17H2,(H,29,31)
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PC sid
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Similars
Article
PubMed
n/an/an/an/a 95n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assay

Bioorg Med Chem Lett 16: 4311-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.058
BindingDB Entry DOI: 10.7270/Q2Z31Z8W
More data for this
Ligand-Target Pair