BDBM50188365 8-[2-(3-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phenyl-2,8-diaza-spiro[4.5]decan-1-one::CHEMBL386444

SMILES: OC1(CCCCC1N1CCC2(CC1)C(CNC2=O)c1ccccc1)c1cccc(F)c1

InChI Key: InChIKey=VTESATXDAMBSLY-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50188365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine transporter 1 (Homo sapiens (Human))	BDBM50188365 (8-[2-(3-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...) Show SMILES OC1(CCCCC1N1CCC2(CC1)C(CNC2=O)c1ccccc1)c1cccc(F)c1 Show InChI InChI=1S/C26H31FN2O2/c27-21-10-6-9-20(17-21)26(31)12-5-4-11-23(26)29-15-13-25(14-16-29)22(18-28-24(25)30)19-7-2-1-3-8-19/h1-3,6-10,17,22-23,31H,4-5,11-16,18H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assay				Bioorg Med Chem Lett 16: 4311-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.058 BindingDB Entry DOI: 10.7270/Q2Z31Z8W
					More data for this Ligand-Target Pair