BDBM50191200 12'-bromo-1-methyl-4'-(naphthalen-1-yl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(13'),4',9',11'-tetraene::CHEMBL214801
SMILES: CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(=NN21)c1cccc2ccccc12
InChI Key: InChIKey=LWRNEFVZZGSMQO-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50191200![]() (12'-bromo-1-methyl-4'-(naphthalen-1-yl)-8'-oxa-5',...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hopital Saint-Louis Curated by ChEMBL | Assay Description Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release | Bioorg Med Chem Lett 16: 4830-3 (2006) Article DOI: 10.1016/j.bmcl.2006.06.068 BindingDB Entry DOI: 10.7270/Q2BV7G7X | |||||||||||
More data for this Ligand-Target Pair |