BDBM50192218 3-(4-tert-butylphenyl)-4-cyano-5-(methylsulfonyl)thiophene-2-carboxylic acid::CHEMBL217111

SMILES: CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)S(C)(=O)=O)C(O)=O

InChI Key: InChIKey=LJUFNIFNORSETG-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192218   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GRIA2 (Homo sapiens (Human))	BDBM50192218 (3-(4-tert-butylphenyl)-4-cyano-5-(methylsulfonyl)t...) Show SMILES CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)S(C)(=O)=O)C(O)=O Show InChI InChI=1S/C17H17NO4S2/c1-17(2,3)11-7-5-10(6-8-11)13-12(9-18)16(24(4,21)22)23-14(13)15(19)20/h5-8H,1-4H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	333	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50192218 (3-(4-tert-butylphenyl)-4-cyano-5-(methylsulfonyl)t...) Show SMILES CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)S(C)(=O)=O)C(O)=O Show InChI InChI=1S/C17H17NO4S2/c1-17(2,3)11-7-5-10(6-8-11)13-12(9-18)16(24(4,21)22)23-14(13)15(19)20/h5-8H,1-4H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50192218 (3-(4-tert-butylphenyl)-4-cyano-5-(methylsulfonyl)t...) Show SMILES CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)S(C)(=O)=O)C(O)=O Show InChI InChI=1S/C17H17NO4S2/c1-17(2,3)11-7-5-10(6-8-11)13-12(9-18)16(24(4,21)22)23-14(13)15(19)20/h5-8H,1-4H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	629	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50192218 (3-(4-tert-butylphenyl)-4-cyano-5-(methylsulfonyl)t...) Show SMILES CC(C)(C)c1ccc(cc1)-c1c(sc(c1C#N)S(C)(=O)=O)C(O)=O Show InChI InChI=1S/C17H17NO4S2/c1-17(2,3)11-7-5-10(6-8-11)13-12(9-18)16(24(4,21)22)23-14(13)15(19)20/h5-8H,1-4H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Lilly S.A. Curated by ChEMBL					Assay Description Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7
					More data for this Ligand-Target Pair