BDBM50192479 (5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine::CHEMBL214753
SMILES: COc1cc2CNc3c(Nc4cc(Cl)ccc4F)ncnc3Oc2cc1OC
InChI Key: InChIKey=WCMSKFSDZXTGKD-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50192479![]() ((5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc Curated by ChEMBL | Assay Description Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assay | Bioorg Med Chem Lett 16: 5102-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.031 BindingDB Entry DOI: 10.7270/Q2K9374T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50192479![]() ((5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc Curated by ChEMBL | Assay Description Inhibition of EGFR autophosphorylation in DiFi cells by ELISA | Bioorg Med Chem Lett 16: 5102-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.031 BindingDB Entry DOI: 10.7270/Q2K9374T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50192479![]() ((5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc Curated by ChEMBL | Assay Description Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assay | Bioorg Med Chem Lett 16: 5102-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.031 BindingDB Entry DOI: 10.7270/Q2K9374T | |||||||||||
More data for this Ligand-Target Pair |