BDBM50192836 CHEMBL3911672::US10188627, Compound 8m

SMILES: CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1

InChI Key: InChIKey=RTCGQTKMNNJMFH-UHFFFAOYSA-N

Data: 5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50192836   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192836 (CHEMBL3911672 | US10188627, Compound 8m) Show SMILES CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-14-12-22(13-15-23)25-7-4-16-33-25)18-24-5-2-3-6-26(24)34-19-21-10-8-20(9-11-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Transactivation of ProLink tagged human PPARdelta transfected in CHO-K1 cells assessed as interaction with EA labelled SRCP after 3 to 16 hrs by beta...				ACS Med Chem Lett 7: 824-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00301 BindingDB Entry DOI: 10.7270/Q2WH2RZ8
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192836 (CHEMBL3911672 | US10188627, Compound 8m) Show SMILES CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-14-12-22(13-15-23)25-7-4-16-33-25)18-24-5-2-3-6-26(24)34-19-21-10-8-20(9-11-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Transactivation of human Gal4-PPARdelta LBD transfected in African green monkey CV1 cells after 24 hrs by luciferase reporter gene assay				ACS Med Chem Lett 7: 824-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00301 BindingDB Entry DOI: 10.7270/Q2WH2RZ8
					More data for this Ligand-Target Pair
PPAR delta protein (Rattus norvegicus (Rat))	BDBM50192836 (CHEMBL3911672 | US10188627, Compound 8m) Show SMILES CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-14-12-22(13-15-23)25-7-4-16-33-25)18-24-5-2-3-6-26(24)34-19-21-10-8-20(9-11-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	13.5	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192836 (CHEMBL3911672 | US10188627, Compound 8m) Show SMILES CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-14-12-22(13-15-23)25-7-4-16-33-25)18-24-5-2-3-6-26(24)34-19-21-10-8-20(9-11-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50192836 (CHEMBL3911672 | US10188627, Compound 8m) Show SMILES CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1 Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-14-12-22(13-15-23)25-7-4-16-33-25)18-24-5-2-3-6-26(24)34-19-21-10-8-20(9-11-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	13.5	n/a	n/a	n/a	n/a
Mitobridge, Inc.; Salk Institute for Biological Studies US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10188627 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FR6
					More data for this Ligand-Target Pair