BDBM50193997 6-(furan-3-yl)-2-(3H-imidazo[4,5-c]pyridin-3-yl)-N-((S)-1-methoxypropan-2-yl)pyrimidin-4-amine::CHEMBL220484::CHEMBL557844

SMILES: COC[C@H](C)Nc1cc(nc(n1)-n1cnc2ccncc12)-c1ccoc1

InChI Key: InChIKey=UTBPYMUVVZGFEJ-LBPRGKRZSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50193997   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193997 (6-(furan-3-yl)-2-(3H-imidazo[4,5-c]pyridin-3-yl)-N...) Show SMILES COC[C@H](C)Nc1cc(nc(n1)-n1cnc2ccncc12)-c1ccoc1 Show InChI InChI=1S/C18H18N6O2/c1-12(9-25-2)21-17-7-15(13-4-6-26-10-13)22-18(23-17)24-11-20-14-3-5-19-8-16(14)24/h3-8,10-12H,9H2,1-2H3,(H,21,22,23)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of JAK3				Bioorg Med Chem Lett 16: 5633-8 (2006) Article DOI: 10.1016/j.bmcl.2006.08.022 BindingDB Entry DOI: 10.7270/Q2J1040K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50193997 (6-(furan-3-yl)-2-(3H-imidazo[4,5-c]pyridin-3-yl)-N...) Show SMILES COC[C@H](C)Nc1cc(nc(n1)-n1cnc2ccncc12)-c1ccoc1 Show InChI InChI=1S/C18H18N6O2/c1-12(9-25-2)21-17-7-15(13-4-6-26-10-13)22-18(23-17)24-11-20-14-3-5-19-8-16(14)24/h3-8,10-12H,9H2,1-2H3,(H,21,22,23)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	446	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of JAK2				Bioorg Med Chem Lett 16: 5633-8 (2006) Article DOI: 10.1016/j.bmcl.2006.08.022 BindingDB Entry DOI: 10.7270/Q2J1040K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193997 (6-(furan-3-yl)-2-(3H-imidazo[4,5-c]pyridin-3-yl)-N...) Show SMILES COC[C@H](C)Nc1cc(nc(n1)-n1cnc2ccncc12)-c1ccoc1 Show InChI InChI=1S/C18H18N6O2/c1-12(9-25-2)21-17-7-15(13-4-6-26-10-13)22-18(23-17)24-11-20-14-3-5-19-8-16(14)24/h3-8,10-12H,9H2,1-2H3,(H,21,22,23)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of JAK3				Bioorg Med Chem Lett 16: 5633-8 (2006) Article DOI: 10.1016/j.bmcl.2006.08.022 BindingDB Entry DOI: 10.7270/Q2J1040K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50193997 (6-(furan-3-yl)-2-(3H-imidazo[4,5-c]pyridin-3-yl)-N...) Show SMILES COC[C@H](C)Nc1cc(nc(n1)-n1cnc2ccncc12)-c1ccoc1 Show InChI InChI=1S/C18H18N6O2/c1-12(9-25-2)21-17-7-15(13-4-6-26-10-13)22-18(23-17)24-11-20-14-3-5-19-8-16(14)24/h3-8,10-12H,9H2,1-2H3,(H,21,22,23)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	141	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of JAK2				Bioorg Med Chem Lett 16: 5633-8 (2006) Article DOI: 10.1016/j.bmcl.2006.08.022 BindingDB Entry DOI: 10.7270/Q2J1040K
					More data for this Ligand-Target Pair