BDBM50194009 6-(3,4-dimethoxyphenyl)-2-(3H-imidazo[4,5-c]pyridin-3-yl)-N-((S)-1-phenylethyl)pyrimidin-4-amine::CHEMBL220483

SMILES: COc1ccc(cc1OC)-c1cc(N[C@@H](C)c2ccccc2)nc(n1)-n1cnc2ccncc12

InChI Key: InChIKey=QRAUCOBDQSCEDZ-KRWDZBQOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50194009   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50194009 (6-(3,4-dimethoxyphenyl)-2-(3H-imidazo[4,5-c]pyridi...) Show SMILES COc1ccc(cc1OC)-c1cc(N[C@@H](C)c2ccccc2)nc(n1)-n1cnc2ccncc12 Show InChI InChI=1S/C26H24N6O2/c1-17(18-7-5-4-6-8-18)29-25-14-21(19-9-10-23(33-2)24(13-19)34-3)30-26(31-25)32-16-28-20-11-12-27-15-22(20)32/h4-17H,1-3H3,(H,29,30,31)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of JAK3				Bioorg Med Chem Lett 16: 5633-8 (2006) Article DOI: 10.1016/j.bmcl.2006.08.022 BindingDB Entry DOI: 10.7270/Q2J1040K
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50194009 (6-(3,4-dimethoxyphenyl)-2-(3H-imidazo[4,5-c]pyridi...) Show SMILES COc1ccc(cc1OC)-c1cc(N[C@@H](C)c2ccccc2)nc(n1)-n1cnc2ccncc12 Show InChI InChI=1S/C26H24N6O2/c1-17(18-7-5-4-6-8-18)29-25-14-21(19-9-10-23(33-2)24(13-19)34-3)30-26(31-25)32-16-28-20-11-12-27-15-22(20)32/h4-17H,1-3H3,(H,29,30,31)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of JAK2				Bioorg Med Chem Lett 16: 5633-8 (2006) Article DOI: 10.1016/j.bmcl.2006.08.022 BindingDB Entry DOI: 10.7270/Q2J1040K
					More data for this Ligand-Target Pair