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BDBM50194714 CHEMBL3910866

SMILES: Fc1cccc(F)c1C1CCN(Cc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)CC1

InChI Key: InChIKey=FGGGMFHQRRVFJH-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194714   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50194714
PNG
(CHEMBL3910866)
Show SMILES Fc1cccc(F)c1C1CCN(Cc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)CC1
Show InChI InChI=1S/C23H23F5N4/c24-17-2-1-3-18(25)20(17)15-6-9-31(10-7-15)13-16-8-11-32-19(12-14-4-5-14)29-30-22(32)21(16)23(26,27)28/h1-3,8,11,14-15H,4-7,9-10,12-13H2
PDB

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 9.70n/an/an/an/a



Janssen Research& Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...

J Med Chem 59: 8495-507 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00913
BindingDB Entry DOI: 10.7270/Q27M09WC
More data for this
Ligand-Target Pair