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BDBM50196712 CHEMBL225637::N-(1-(4-methoxybenzyl)piperidin-3-yl)-1H-indazol-5-amine::N-[1-(4-methoxybenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amine

SMILES: COc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1

InChI Key: InChIKey=UCJIXVPTONWDEH-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50196712   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2/Rho-kinase (ROCK I)


(Homo sapiens (Human))
BDBM50196712
PNG
(CHEMBL225637 | N-(1-(4-methoxybenzyl)piperidin-3-y...)
Show SMILES COc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C20H24N4O/c1-25-19-7-4-15(5-8-19)13-24-10-2-3-18(14-24)22-17-6-9-20-16(11-17)12-21-23-20/h4-9,11-12,18,22H,2-3,10,13-14H2,1H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of Rho kinase


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
BindingDB Entry DOI: 10.7270/Q2T43TW5
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50196712
PNG
(CHEMBL225637 | N-(1-(4-methoxybenzyl)piperidin-3-y...)
Show SMILES COc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C20H24N4O/c1-25-19-7-4-15(5-8-19)13-24-10-2-3-18(14-24)22-17-6-9-20-16(11-17)12-21-23-20/h4-9,11-12,18,22H,2-3,10,13-14H2,1H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Kirin Brewery Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of MCP1-induced cell migration in U937 cells expressing CCR2 by chemotaxis assay


Bioorg Med Chem 15: 350-64 (2006)


Article DOI: 10.1016/j.bmc.2006.09.052
BindingDB Entry DOI: 10.7270/Q2T43TW5
More data for this
Ligand-Target Pair