BDBM50197991 3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-pyrazol-5-yloxy)-N-(1-(diethylamino)-6-methyloctan-4-yl)propanamide::CHEMBL239170

SMILES: CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=LOUSLMDIWLUSPD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50197991   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50197991 (3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...) Show SMILES CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1 |w:5.13,2.2| Show InChI InChI=1S/C35H44Cl2N4O2/c1-5-25(4)19-31(13-10-17-40(6-2)7-3)38-34(42)16-18-43-35-24-33(28-20-29(36)23-30(37)21-28)39-41(35)32-15-14-26-11-8-9-12-27(26)22-32/h8-9,11-12,14-15,20-25,31H,5-7,10,13,16-19H2,1-4H3,(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytes				Bioorg Med Chem Lett 17: 807-13 (2007) Article DOI: 10.1016/j.bmcl.2006.10.060 BindingDB Entry DOI: 10.7270/Q2P84BJD
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50197991 (3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...) Show SMILES CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1 |w:5.13,2.2| Show InChI InChI=1S/C35H44Cl2N4O2/c1-5-25(4)19-31(13-10-17-40(6-2)7-3)38-34(42)16-18-43-35-24-33(28-20-29(36)23-30(37)21-28)39-41(35)32-15-14-26-11-8-9-12-27(26)22-32/h8-9,11-12,14-15,20-25,31H,5-7,10,13,16-19H2,1-4H3,(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Tehran University of Medical Sciences Curated by ChEMBL					Assay Description Inhibition of CCR2				Eur J Med Chem 45: 3394-406 (2010) Article DOI: 10.1016/j.ejmech.2010.04.024 BindingDB Entry DOI: 10.7270/Q2JQ1275
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50197991 (3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...) Show SMILES CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1 |w:5.13,2.2| Show InChI InChI=1S/C35H44Cl2N4O2/c1-5-25(4)19-31(13-10-17-40(6-2)7-3)38-34(42)16-18-43-35-24-33(28-20-29(36)23-30(37)21-28)39-41(35)32-15-14-26-11-8-9-12-27(26)22-32/h8-9,11-12,14-15,20-25,31H,5-7,10,13,16-19H2,1-4H3,(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 mins				Bioorg Med Chem Lett 17: 807-13 (2007) Article DOI: 10.1016/j.bmcl.2006.10.060 BindingDB Entry DOI: 10.7270/Q2P84BJD
					More data for this Ligand-Target Pair