BDBM50198374 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]-pyrazin-5-yl]-N,N-dimethylbenzamide::CHEMBL374376

SMILES: CN(C)C(=O)c1ccc(cc1)-c1cnc(Nc2c(C)cccc2C)c2cncn12

InChI Key: InChIKey=FXJRVQWKPAGAQH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50198374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50198374 (4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]-pyraz...) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cnc(Nc2c(C)cccc2C)c2cncn12 Show InChI InChI=1S/C23H23N5O/c1-15-6-5-7-16(2)21(15)26-22-20-12-24-14-28(20)19(13-25-22)17-8-10-18(11-9-17)23(29)27(3)4/h5-14H,1-4H3,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of cSrc by coupled spectrophotometric enzyme assay				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
					More data for this Ligand-Target Pair