Found 4 hits for monomerid = 50200533 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50200533
(CHEMBL3904539)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H22FN9O/c22-13-2-1-6-26-19(13)16-4-3-12-8-27-21(31(12)29-16)28-17-9-25-7-5-18(17)30-10-14(23)20(32)15(24)11-30/h1-9,14-15,20,32H,10-11,23-24H2,(H,27,28)/t14-,15+,20+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50200533
(CHEMBL3904539)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H22FN9O/c22-13-2-1-6-26-19(13)16-4-3-12-8-27-21(31(12)29-16)28-17-9-25-7-5-18(17)30-10-14(23)20(32)15(24)11-30/h1-9,14-15,20,32H,10-11,23-24H2,(H,27,28)/t14-,15+,20+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50200533
(CHEMBL3904539)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H22FN9O/c22-13-2-1-6-26-19(13)16-4-3-12-8-27-21(31(12)29-16)28-17-9-25-7-5-18(17)30-10-14(23)20(32)15(24)11-30/h1-9,14-15,20,32H,10-11,23-24H2,(H,27,28)/t14-,15+,20+ | UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
1,3-beta-glucan synthase component GSC2
(Saccharomyces cerevisiae) | BDBM50200533
(CHEMBL3904539)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H22FN9O/c22-13-2-1-6-26-19(13)16-4-3-12-8-27-21(31(12)29-16)28-17-9-25-7-5-18(17)30-10-14(23)20(32)15(24)11-30/h1-9,14-15,20,32H,10-11,23-24H2,(H,27,28)/t14-,15+,20+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of radiolabeled dofetilide binding to human ERG expressed in HEK293 cells |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
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